Physics of Fluids - Publications

Luminescence thermometry for in situ temperature measurements in microfluidic devices

Lab on a Chip 19, 1236–1246 (2019)

Authors

BibTeΧ

@Article{C8LC01292J,
author ="Geitenbeek, Robin G. and Vollenbroek, Jeroen C. and Weijgertze, Hannah M. H. and Tregouet, Corentin B. M. and Nieuwelink, Anne-Eva and Kennedy, Chris L. and Weckhuysen, Bert M. and Lohse, Detlef and van Blaaderen, Alfons and van den Berg, Albert and Odijk, Mathieu and Meijerink, Andries",
title  ="Luminescence thermometry for in situ temperature measurements in microfluidic devices",
journal  ="Lab Chip",
year  ="2019",
volume  ="19",
issue  ="7",
pages  ="1236-1246",
publisher  ="The Royal Society of Chemistry",
doi  ="10.1039/C8LC01292J",
url  ="http://dx.doi.org/10.1039/C8LC01292J",
abstract  ="Temperature control for lab-on-a-chip devices has resulted in the broad applicability of microfluidics to{,} e.g.{,} polymerase chain reaction (PCR){,} temperature gradient focusing for electrophoresis{,} and colloidal particle synthesis. However{,} currently temperature sensors on microfluidic chips either probe temperatures outside the channel (resistance temperature detector{,} RTD) or are limited in both the temperature range and sensitivity in the case of organic dyes. In this work{,} we introduce ratiometric bandshape luminescence thermometry in which thermally coupled levels of Er3+ in NaYF4 nanoparticles are used as a promising method for in situ temperature mapping in microfluidic systems. The results{,} obtained with three types of microfluidic devices{,} demonstrate that temperature can be monitored inside a microfluidic channel accurately (0.34 °C) up to at least 120 °C with a spot size of ca. 1 mm using simple fiber optics. Higher spatial resolution can be realized by combining luminescence thermometry with confocal microscopy{,} resulting in a spot size of ca. 9 μm. Further improvement is anticipated to enhance the spatial resolution and allow for 3D temperature profiling."}

	R.G. Geitenbeek
	J.C. Vollenbroek
	H.M.H. Weijgertze
	Corentin Tregouet
	A.E. Nieuwelink
	C.L. Kennedy
	Bert Weckhuysen
	Detlef Lohse
	A. van Blaaderen
	Albert van den Berg
	Mathieu Odijk
	A. Meijerink